Tools
On this page, I try to keep track of resource I think can be useful to psychiatry residents. In each section, I try my best to order by most important first.
Enzymatic interaction
- Seems rather complete and was recommended to me: ClinPGx (formerly PharmGKB).
- I noticed at least once a pretty wild oversimplification: the text on ClinPGx mentioned one cytochrome as being the main one, while the source actually explained that this one was actually the one that bound to the molecule the most but because it was less present it was actually not the main metabolizer of the given drug.
- My conclusion is that the most reliable way to check enzymatic drug pathways is to use ClinPGx to reason but then read all the underlying sources’s abstracts to reduce the chances of this happening again.
- Seemed promising, seems to cite sources extensively but not yet sure about exhaustivity, 2021 initially but updated twice a year apparently:
- But: does not mention lamotrigin, and only a subset of the known venlafaxin interactions.
- Drug Interaction Flockhart Table
- In French from switzerland:
- Good table, was often recommended to me, 2017: Interactions médicamenteuses, cytochromes P450 et P-glycoprotéine (Pgp)
- Only about antidepressants, 2013: Dosage plasmatique des médicaments antidépresseurs
- This research website seemed to contain promising tools but they seemed to handle pretty badly their HTTPS certificates, 2020:
General drug information
- ClinPGx (formerly PharmGKB) (described above).
- The
Resume des Caracteristiques du Produitaccessed through the Base de donnee publique du medicament. - Vidal as well as Hoptimal Vidal (“hospital” version).
- To know which drugs is unavailable to patients: Disponibilité des produits de santé